Green Sustainable and Efficient Protocol to Perform a New Series of Imino Fused Pyrimido[1,2-a] Pyrimidine-3-Carbonitrile
Pyrimido-pyrimidine compounds are supreme type of fused heterocyclic ring system involves two pyrimidine fused ring. These scaffold derived compounds have been reported to acquired significant interest activity researched in medicinal chemistry for their therapeutic potential in treating various diseases due to their diverse biological activities, including potential use as antibacterial, anticancer, anti inflammatory antimicrobial, Inhibition of enzymes like Bruton's tyrosine kinase (BTK), antibacterial, anti-allergic, antiviral, and antihypertensive agents. Beyond pharmaceuticals, they are used wiedly in materials science for optoelectronics (OLEDs, dyes) and agrochemicals (herbicides) and function as fluorescent probes and corrosion inhibitors, highlighting their diverse roles in both biological and material systems. Thus, many researchers have reported various synthetic methods for synthesizing different isomers of pyrimidopyrimidines, so, in this work. In this research a sustainable green pathway was used to performed a new series of pyrimido [1,2-9 ]pyrimidine-3-carbonitrile (1-3) via rapid and sufficiently solid phase one-pot three component reaction of substituted benzaldehyde, malononitrile and 2-amino-5-nitro pyrimidine , the reaction proceeded through green chemistry technique represented by catalyst free microwave irradiation condition reaction and also with simple work up , yield enhancement , economic and also no pollution was adopted, so and in the other word, it is very eco friendly. These compounds (1-3) were then condensed with benzaldehyde to afford supreme type of Schiff base with different and distinctive properties in acidic conditions from glacial acetic acid (2-3 drops). All prepared compounds were illustrated by available physical and spectral methods represented by TLC, M.P., FT-IR, 1H-NMR and GC-Mass.