New 5,6-Dihydro Pyrimidine Derivatives, Synthesis, Characterization and antibacterial activity
In this study, five Schiff base compounds were prepared by the reaction between one mole of benzil with one mole of the below five types of amines: (aniline, 1 – naphthalamine, 4-nitroaniline, 4-chloroaniline, and 4-aminobenzoic acid). Such products were transferred into chalcone by reacting them with acetone. The resulted compounds were reacted with urea to prepare five derivatives of imine – based 5,6 – dihydropyrimidin – 2(1H) – one. Such resulted compounds were traced via spectrometry [MASS, (1H, 13C NMR) and FTIR]. The results conformed with the expected compounds. The biological activity of the synthesized compounds was then tested against two types of bacteria (Staphylococcus aureus and E-coli). It has been approved accordingly that such prepared compounds have a moderate effect against bacteria.