Palladium N2O2 Schiff Base Complexes: Structure, Biological Activity and Medicinal Applications- A Review
Palladium N2O2 Schiff base complexes are an exciting area in medicinal chemistry due to their unique structure and impressive biological activities. These compounds form when palladium salt coordinates with tetradentate Schiff base ligands that have two nitrogen and two oxygen donor atoms. They mostly take on a stable square planar shape. This clear coordination setup is key to their reliable interactions with biological targets. Research shows they have significant potential as therapeutic agents, especially in anticancer, antimicrobial, and antioxidant uses. Often, they are more effective than their Schiff base ligands and, in some cases, even better than established clinical drugs like cisplatin, with potentially less toxicity. These complexes also show great catalytic activity in various organic synthesis, demonstrating their versatile usefulness. Their instinctive stability, combined with their easiness in synthesis, makes them strong candidates for drug design and the development of new pharmaceuticals.