Spectral Analysis, Molecular Docking and Antibacterial Evaluation of Copper (II) Complexes with Substituted Thiosemicarbazone Ligand
Copper (II) complexes of diethylaminosalicylaldehyde 4-ethyl thiosemicarbazone were synthesized and characterized by UV, IR and EPR spectroscopic methods. The formula of complexes were [CuL.H2O], [CuL]2 and [Cu(H2L)SO4] based on elemental analyses which provide information about the composition of the complexes in terms of the elements present. The molar conductivity values show that these complexes are non-conductors and suggest that they are likely molecular compounds rather than ionic compounds. The results of EPR spectra show that all the three complexes are four coordinated complexes with unpaired electron in the dx2-y2 orbital. Molecular docking with receptors of colon cancer (2hq6) and lung cancer (1x2j) show their cytotoxic potential. The complexes have biological activity against the bacterial strains Escherichia coli and Staphylococcus aureus proving their antimicrobial action. The complex [Cu(H2L)SO4] shows maximum antibacterial activity.