Study of Vitamin D levels with some minerals in serum of breast cancer patients and their relationship to its progression
Breast cancer is the leading cause of cancer-related deaths in women, presenting a complex, multi-step progression involving diverse cell types. Anticipating and managing breast cancer remains a global challenge. The vitamin D receptor (VDR), responding to the active form of vitamin D (1,25D), exhibits antitumor effects, suggesting a crucial tumor-suppressing role in mammary tissue. When activated by 1,25D, VDR regulates various cellular pathways. Pre-clinical evidence strongly links vitamin D status to breast cancer development. Our study, involving 80 women (40 breast cancer patients and 40 controls, aged 18–45), assesses vitamin D levels and their correlation with breast cancer progression. Results indicate lower vitamin D and phosphorus levels in patients compared to controls, emphasizing potential deficiencies in carcinogenesis. Despite higher calcium levels in controls, the difference is not significant. In conclusion, insufficient vitamin D levels and mineral imbalances may contribute to breast cancer progression, warranting further research.