Synthesis and Characterization of Novel Dendritic Polymer as Drug Carrier for, Wounds and Burns Therapy Applications
This paper details the synthesis of a novel dendrimer employing a divergent growth methodology, commencing with a meticulously constructed core and advancing through numerous generations (up to G7). Techniques such as NMR and FTIR elucidated the dendrimer's structure, validating its solubility and thermal stability. The radical photopolymerization of the dendrimer with vinyl monomers produced a novel heteropolymer. When used to treat skin wounds, this polymer effectively improves the delivery of lycoperdon lividum, leading to better therapeutic outcomes compared to control groups. During a 21-day period, we found significant reductions in wound size, accompanied by increases in oxidative stress indicators (MDA, SOD, GSH, and CAT), indicating biochemical changes pertinent to the healing process. The results suggest that this dendrimer-based polymer system holds promise for effective wound treatment, underscoring the importance of biocompatible polymer systems in therapeutic applications.