Synthesis of new heterocyclic derivatives derived from 1-aminonaphthalene and evaluation of its biological activity and molecular docking
The aim of this study is to synthesize new heterocyclic organic derivatives, where the process was carried out in several steps, in the first step Schiff bases compounds prepared from reaction of (1-aminonaphthalene) with aldehydes (salicylaldehyde and furfural) to prepare compounds A and B. The second step was the reaction of derivatives A and B with sodium azide, phthalic anhydride and thioglycolic acid to prepare derivatives of tetrazole (A1 and B1), oxazepine (A2 and B2) and thiazolidine (A3 and B3). All of the derivatives were characterized by FT-IR, 1H-NMR and 13C-NMR spectroscopy. The third step included studying the biological activity of the compounds that were prepared through the extent of their inhibition effectiveness against two types of bacteria: gram-negative bacteria (Escherichia coli) and Gram-positive bacteria (Staphylococcus). The effectiveness of the derivatives has been theoretically studied against prostate cancer through Molecular Docking programs against the 1E3G protein, which is related to this disease..